Published on March 15, 2012 by

Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples – a Cochrane Systematic Review

Observational studies suggest that sexual transmission of HIV may be lower in couples in which one partner is infected with HIV and the other is not (HIV-discordant couples) if the infected partner is on antiretroviral therapy (ART). If ART does confer a prevention benefit, in addition to its well established therapeutic efficacy, it may be an indication to initiate treatment earlier than currently recommended. Recently a systematic review was conducted on the issue and based on the evidence provided by one randomised controlled trial and seven observational cohort studies, ART has been shown to be a potent intervention for prevention of HIV in discordant couples. More results of the review are reported here, as well as the implications for practice and research.