It is estimated that worldwide nearly a million people per annum suffer major cardiovascular complications following noncardiac surgery. These complications include cardiac death, myocardial infarction (heart attack) and cardiac arrest. Unfortunately, collaboration in perioperative cardiovascular research remains in its infancy, and only recently there has been the development of large collaborative groups to investigate perioperative cardiovascular outcomes. Furthermore, the epidemiology and pathophysiology of perioperative cardiovascular disease is poorly understood. Mathematical modelling should be considered an integral component of perioperative cardiovascular research due to the nature and complexity of the outcomes associated with these studies.