Cari van Schalkwyk

Short item Published on September 14, 2017

Progress in HIV science illuminated at the IAS2017 conference

The biennial International AIDS Society (IAS) Conference on HIV Science was held in Paris, France in July 2017. This article presents some of the highlights of the conference, including the roll of PrEP and the promise of long-acting injectable ARVs, as well as contributions of SACEMA staff in the areas of HIV and Hepatitis C, and HIV and cervical cancer. Basic, clinical, epidemiological and operational research on HIV and the HIV response must continue to be prioritised even while we strengthen our health systems and improve the implementation of existing interventions.

Short item Published on March 17, 2015

Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa

Household contacts of active TB cases are at increased risk of TB infection and several studies have measured TB prevalence in this key population. The study described here not only measured TB prevalence, but also measured TB and HIV incidence in the household contacts of 729 TB index cases in the Matlosana sub-district in North West Province. We concluded that the efficacy of contact tracing for TB control purposes might be improved by a second intensified case finding visit and by providing preventive treatment against TB for both HIV-infected and HIV-seronegative household contacts of TB cases.

Short item Published on March 13, 2014

Outcomes and impact of HIV prevention, ART and TB programmes in Swaziland – early evidence from public health triangulation.

In 2011, the Ministry of Health in Swaziland joined forces with the WHO, the Global Fund and SACEMA to do the first in depth health programmes progress evaluation using triangulation from key empirical data sources. The focus was on key questions like: Given increasing coverage of ART, has ART reduced adult and/or infant mortality?; Can TB trends be related to trends in HIV prevalence, ART coverage and combined TB/HIV interventions?; Can trends in infant mortality be related to uptake of PMTCT?

Published on March 18, 2013 by

Different ways to estimate the mean duration of “recent HIV infection” as measured by the BED assay

Robust affordable means for estimating HIV incidence at the population level continue to be elusive and much desired. As resources are invested in developing more appropriate tests for recent infection, the methods for evaluating and optimising the performance of candidate tests need to be further refined. We have recently explored a range of statistical methods for estimating the mean duration of recent infection (MDRI) by investigating a data set from Harare, Zimbabwe. We investigated whether there is an optimum way of estimating the mean recency duration for this dataset. We also ask how estimates of the mean recency duration and incidence are affected by our choice of cut-off and whether these effects differ with our choice of estimation method.