Foot-and-mouth disease (FMD) can affect a range of animals, including livestock. In South Africa, successful control has eliminated the infection from most of the country, however, infection risk remains in the areas surrounding the Kruger National Park. African buffalo (Syncerus caffer) maintain a high prevalence of FMD. Understanding how buffalo maintain the infection, when transmission from buffalo is most likely, and why transmission occurs are important to understanding FMD in South Africa. This article discusses an individual-based model that is guiding our field and experimental data collection in Kruger National Park.