Short item Published on June 15, 2016

The Cancer Stem Cell Paradigm and Mathematical Modelling – A Brief Summary

It is believed that most tumours are heterogeneous and many cancers contain small populations of highly tumorigenic and intrinsically drug resistant cancer stem cells (CSCs). Gaining deeper insights into the development of stem cells in general and CSCs in particular with the aim of interfering with the emerging CSC population for the purpose of bringing about its eradication poses challenges to biomedical research and engenders approaches from various viewpoints including by mathematical modelling. We used an ordinary differential equation formulation to study a nonlinear model that was based on normal and abnormal cells, including CSC, behaviour in the bone marrow and peripheral blood.