Wim Delva

Published on November 30, 2018 by

Open Communication as an Integral Part of Open Science

Open communication has always been at the heart of the SACEMA Quarterly. Ever since the first issue of the magazine, in March 2009, the aim of the Quarterly has been to provide regular updates, articles, and reviews of developments in the world of quantitative epidemiology. This issue will be the last SACEMA Quarterly. We are thankful for your interest in our work through the years.

Published on November 30, 2018 by

SimpactCyan 1.0: An Open-source Simulator for Individual-Based Models in HIV Epidemiology

In epidemiology, mathematical models are widely used to simulate progression, transmission, prevention and treatment of infectious diseases. Individual-based models (IBMs) keep track of the events that happen to each individual separately and are therefore able to take into account various sources of individual heterogeneity. SimpactCyan is conceived as a multipurpose model-building tool to address research questions in HIV epidemiology at the intersection of network and social epidemiology, computational biology, public health and policy modelling. With SimpactCyan we aim to overcome some of the limitations of current software for implementing IBMs in HIV epidemiology.

Published on November 30, 2017 by

Editorial: On complexity, realism and usefulness of individual-based models

For individual-based models (IBMs) in epidemiology, thinking about links between a model’s complexity, its closeness to reality and its usefulness is pertinent. This is because the bottom-up, modular and hierarchical structure of this type of models makes it relatively easy to increase the level of heterogeneity and complexity represented by the model. Moreover, the rationale for doing so is often a desire to build more realistic models. The implicit belief is that by virtue of being more realistic, models also become more useful. But is this necessarily true?

Short item Published on June 15, 2017

The excitement and challenges of introducing an introductory course

Two months ago Lander Willem and I organized the first edition of the short course “Individual-based modelling in epidemiology: A practical introduction”. The feedback at the end of the course was overwhelmingly positive, which left us feeling empowered and encouraged to not leave it at this first edition. Participants of the next edition should expect an even more hands-on course, with more time to acquire skills in developing, exploring and fitting individual-based models.

Published on March 15, 2017 by

Editorial: Rethinking our indicators of impact and excellence

As epidemiologists we constantly think about indicators and metrics. Given the well-known limitations of simplifying complex dependencies to one-dimensional indicators, isn’t it surprising that many academics have bought into the practice of measuring the quality and impact of their work by a handful of metrics? While books have been written about the need for more and better indicators of impact and excellence in academia, surprisingly little attention is given to the challenge and value of being engaged and excelling in non-academic activities. Some ideas around this are presented in this editorial.

Short item Published on March 15, 2017

Beyond risk compensation: Clusters of antiretroviral treatment users in sexual networks can modify the impact of ART on HIV incidence

Early initiation of antiretroviral therapy (ART) significantly improves the survival of people living with HIV (PLWH) and reduces HIV transmission to uninfected partners. Mathematical models suggest that treatment-as-prevention programmes could lead to HIV elimination. How the clinical efficacy of ART in preventing HIV transmission translates to real-life settings depends in large part on the capacity of HIV programmes to engage and retain PLWH. The effects of ART on HIV incidence may also depend on changes in sexual network dynamics during the course of ART scale-up which are discussed in this article.

Published on September 14, 2016 by

Connecting the dots: network data and models in HIV epidemiology

Effective HIV prevention requires knowledge of the structure and dynamics of the social networks across which infections are transmitted. These networks are most commonly comprised of chains of sexual relationships. Whereas network data have long been collected during survey interviews, new data sources have become increasingly common in recent years. In this article, we review current and emerging methods for collecting HIV-related network data, as well as modelling frameworks commonly used to infer network parameters and map potential HIV transmission pathways within the network.

Published on September 15, 2015 by

Editorial: Making progress in epidemiology through interactive storytelling

Policy makers, fellow scientists, media reporters and students are more likely to pay attention to epidemiologists who are able to articulate new research findings through a captivating narrative, a vivid mental picture or a striking infographic. Recent software developments have made it easy to produce web applications and reports that dynamically combine text, mathematical expressions, code chunks and the output of complex computations. The result is that researchers can adopt a more engaging, interactive form of storytelling.

Published on November 25, 2014 by

Editorial: The value of models in maternal and child health research

2015 signifies the deadline for the Millennium Development Goals (MDGs) which include reduction of the under-five mortality rate by two-thirds, reduction of the maternal mortality ratio by three quarters (both relative to the 1990 figures), and universal access to reproductive health. This issue of the SACEMA Quarterly focuses on various aspects of maternal and child health, and the role of statistical and mathematical modelling techniques in this area of research.

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